The Crystal and Molecular Structure of 8,2'-Cycloadenosine Trihydrate BY S. NEIDLE,* G. L. TAYLOR AND P. C. COWLING
نویسندگان
چکیده
8,2'-Cycloadenosine, C IoHi~NsO4.3H20, is a modified arabinosyladenosine nucleoside which has been cyclized at the C(8) and 0(2 ' ) atoms. THe trihydrate crystallizes in the orthorhombic space group P2~2~2~, with a = 8.680 (2), b = 5.991 (2), c = 27.203 (4) A, Z = 4. The structure was refined to R = 0.0672 for 1411 unique reflections, photographically recorded. The arabinofuranose ring has a flattened C(4')-endo-C(3')exo pucker. The conformation about C(4 ' ) -C(5 ' ) is gauche-gauche, and that about the sugar-base bond is high anti. The crystal structure involves extensive base-base hydrogen bonding, N(1), N(6) and N(7) all being participants.
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Motteram, R. (1951). 7. Path. Bact., 63, 389. Packard, R. S. (1960). Gut, 1, 171. Palmer, E. D. (1954). Medicine (Baltimore), 33, 199. Registrar-General (1958). The Registrar-General's Decennial Supplement, England and Wales, 1951. Occupational Mortality, Part II, Vol. 2, Tables. H.M.S.O., London. Schoen, A. M. (1963). In Gastroenterology, Vol. 1, edited by H. L. Bockus, 2nd ed. Saunders, Phila...
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